HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous Chloride → 2-Amino-4-methyl-N-quinolin-8-yl-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | 4-methyl-2-nitro-N-quinolin-8-ylbenzenesulfonamide | HCID 973504 | — |
| Catalyst | Hydrochloric Acid | HCID 313 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Amino-4-methyl-N-quinolin-8-yl-benzenesulfonamide | HCID 16759922 | 45.5% |
Reaction Steps
In a similar fashion using route 1 general procedure 4, 4-methyl-2-nitro-N-quinolin-8-yl-benzenesulfonamide (Intermediate 265) (1.3 g, 3.79 mmol), SnCl2 (2.87 g, 15.1 mmol), 6N HCl (2 drops) and EtOH (10 ml) at 85° C. for 6 h gave the title compound (540 mg, 45%) which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-a8c72cf4d35a461fa30df8db660f3a08 |
| Source note | uspto-grants-2015_08 |