HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous Chloride → HCID 68183321, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | 5-Methyl-2-nitro-N-quinolin-8-yl-benzenesulfonamide | HCID 68183157 | — |
| Catalyst | Hydrochloric Acid | HCID 313 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 68183321 | HCID 68183321 | 50.1% |
Reaction Steps
In a similar fashion using route 1 general procedure 4, 5-methyl-2-nitro-N-quinolin-8-yl-benzenesulfonamide (Intermediate 266) (350 mg, 1.02 mmol), SnCl2 (773 mg, 4.08 mmol), 6N HCl (5 drops) and EtOH (5 ml), at 80° C. for 2 h gave the title compound (160 mg, 50%) after purification by column chromatography with n-hexane/EtOAc (98:2) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-7310400fabff4a099dd7b5cd49548e92 |
| Source note | uspto-grants-2015_08 |