HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 2-Amino-N-(6-methoxy-quinolin-8-yl)-4-methyl-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | N-(6-methoxyquinolin-8-yl)-4-methyl-2-nitrobenzenesulfonamide | HCID 16759965 | — |
| Catalyst | Nickel | HCID 935 | — |
| Product | 2-Amino-N-(6-methoxy-quinolin-8-yl)-4-methyl-benzenesulfonamide | HCID 16759911 | 44% |
Reaction Steps
In a similar fashion using route 6 general procedure 14, N-(6-methoxyquinolin-8-yl)-4-methyl-2-nitro-benzenesulfonamide (Intermediate 153) (150 mg, 0.40 mmol), Raney nickel (30 mg, 20% wt) and hydrazine hydrate (64 mg, 1.21 mmol) gave title compound (60 mg, 44%) after purification by column chromatography with DCM as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-dbc0737d9ec64d7589b919d28d976ca0 |
| Source note | uspto-grants-2015_08 |