HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → HCID 60164001, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | HCID 68183035 | HCID 68183035 | — |
| Catalyst | Nickel | HCID 935 | — |
| Product | HCID 60164001 | HCID 60164001 | 59% |
Reaction Steps
In a similar fashion using route 6 general procedure 14, N-(6-methoxyquinolin-8-yl)-2-nitro-4-(trifluoromethyl)benzenesulfonamide (Intermediate 154) (200 mg, 0.47 mmol), Raney nickel (40 mg, 20% wt), hydrazine hydrate (70 μl, 1.41 mmol) gave the title compound (110 mg, 59%) after purification by column chromatography with DCM as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-9d784d14f29c463c929a843ff7a60af7 |
| Source note | uspto-grants-2015_08 |