HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 2-Amino-N-(5-chloroquinolin-8-yl)-4-methyl-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | N-(5-chloroquinolin-8-yl)-4-methyl-2-nitrobenzenesulfonamide | HCID 68183028 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Amino-N-(5-chloroquinolin-8-yl)-4-methyl-benzenesulfonamide | HCID 68183369 | 27.4% |
Reaction Steps
In a similar fashion using route 6 general procedure 14, N-(5-chloroquinolin-8-yl)-4-methyl-2-nitrobenzenesulfonamide (Intermediate 155) (160 mg, 0.42 mmol), Raney nickel (32 mg, 20% wt), hydrazine hydrate (63 mg, 1.27 mmol) and MeOH (10 ml) gave the title compound (40 mg, 27%) after purification by column chromatography with DCM as the eluent followed by recrystallisation from DCM/n-pentane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-b20cd9743a174eae814829f53ca41788 |
| Source note | uspto-grants-2015_08 |