HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydrazine hydrate (1:1) → 2-Amino-N-(5-chloroquinolin-8-yl)-4-trifluoromethyl-benzenesulfonamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Edukt | N-(5-Chloroquinolin-8-yl)-2-nitro-4-trifluoromethylbenzenesulfonamide | HCID 68182997 | — |
| Katalysator | Nickel | HCID 935 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | 2-Amino-N-(5-chloroquinolin-8-yl)-4-trifluoromethyl-benzenesulfonamide | HCID 68183012 | 27% |
Reaktionsschritte
In the similar fashion using route 6 general procedure 14, N-(5-chloroquinolin-8-yl)-2-nitro-4-trifluoromethylbenzenesulfonamide (Intermediate 156) (120 mg, 0.28 mmol), Raney nickel (24 mg, 20% wt), hydrazine hydrate (40 μl, 0.84 mmol), MeOH (3 ml) gave the title compound (30 mg, 27%) after purification by column chromatography with DCM/MeOH (199:1) as the eluent.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09102688B2 |
| Quelldatensatz | uspto-grants-2015_08 |
| ORD ID | ord-917204f6d7444dff935aa1ec7f7f86c6 |
| Quellennotiz | uspto-grants-2015_08 |