Hydrazine hydrate (1:1) → HCID 68182972, compound

Participants

Reaction Steps

In a similar fashion using route 6 general procedure 14, 4-methyl-N-(3-methylquinolin-8-yl)-2-nitrobenzenesulfonamide (Intermediate 157) (100 mg, 0.28 mmol), Raney nickel (20 mg, 20% wt), hydrazine hydrate (42 mg, 0.84 mmol) and MeOH/THF (4:1, 5 ml) gave the title compound (20 mg, 22%) after purification by column chromatography with n-hexane/EtOAc (1:0-4:1) gradient elution.

Provenance & Evidence