HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → HCID 68183388, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | HCID 68183005 | HCID 68183005 | — |
| Catalyst | Nickel | HCID 935 | — |
| Product | HCID 68183388 | HCID 68183388 | 22.5% |
Reaction Steps
In a similar fashion using route 6 general procedure 14, N-(3-Methylquinolin-8-yl)-2-nitro-4-trifluoromethylbenzenesulfonamide (Intermediate 158) (60 mg, 0.14 mmol), Raney nickel (10 mg, 20% wt) and hydrazine hydrate (20 mg, 0.43 mmol) gave the title compound (12 mg, 22%) after purification by column chromatography with DCM as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-bf0e7c9bb266489aa7f100e42f2e9055 |
| Source note | uspto-grants-2015_08 |