HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isobutyryl chloride → HCID 68183069, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isobutyryl chloride | HCID 62325 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-Amino-N-quinolin-8-yl-4-trifluoromethyl-benzenesulfonamide | HCID 16759548 | — |
| Product | HCID 68183069 | HCID 68183069 | 43% |
Reaction Steps
In a similar fashion using route 15 general procedure 30, 2-amino-N-(quinolin-8-yl)-4-trifluoromethyl-benzenesulfonamide (Example Compound 35) (40 mg, 0.11 mmol), isobutyryl chloride (11 μl, 0.11 mmol) and DIPEA (47 μl, 0.27 mmol) gave the title compound (20 mg, 43%) after purification by column chromatography with DCM/n-hexane (4:1) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-794e8e4b40cf43a4bc5f48ff920f5d8a |
| Source note | uspto-grants-2015_08 |