HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → N-[2-(Quinolin-8-ylsulfamoyl)-5-trifluoromethyl-phenyl]-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-Amino-N-quinolin-8-yl-4-trifluoromethyl-benzenesulfonamide | HCID 16759548 | — |
| Product | N-[2-(Quinolin-8-ylsulfamoyl)-5-trifluoromethyl-phenyl]-acetamide | HCID 68183415 | 36% |
Reaction Steps
In a similar fashion using route 15 general procedure 30, 2-amino-N-(quinolin-8-yl)-4-trifluoromethyl-benzenesulfonamide (Example Compound 35) (50 mg, 0.14 mmol), acetyl chloride (9 μl, 0.14 mmol) and DIPEA (59 μl, 0.34 mmol) gave the title compound (20 mg, 36%) after purification by column chromatography with DCM/n-hexane (4:1) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-96fd5167d1b34b0990a048f886ab2cb9 |
| Source note | uspto-grants-2015_08 |