Acetic Acid → 11-Methoxy-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide

Participants

Reaction Steps

In a similar fashion using route 16 general procedure 31, 2-amino-N-(6-methoxyquinolin-8-yl)-benzenesulfonamide (Intermediate 169) (100 mg, 0.30 mmol), acetic acid (0.02 ml, 0.32 mmol) and tert-butyl nitrite (60 mg, 0.61 mmol) gave the title compound (19 mg, 36%) after purification by column chromatography with DCM/n-hexane (9:1-1:0) followed by DCM/MeOH (199:1) gradient elution.

Provenance & Evidence