Acetic Acid → HCID 68183346, compound

Participants

Reaction Steps

In a similar fashion using route 16 general procedure 31, 2-amino-N-(5-methoxyquinolin-8-yl)-benzenesulfonamide (Intermediate 177) (200 mg, 0.61 mmol), acetic acid (36 mg, 0.61 mmol), tert-butyl nitrite (93 mg, 0.91 mmol) gave the title compound (25 mg, 13%) after purification by column chromatography using silica basified by TEA with DCM/MeOH (1:0-499:1) as the eluent.

Provenance & Evidence