Tert-Butyl nitrite → 12-Fluoro-9-trifluoromethyl-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide

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Reaction Steps

In a similar fashion using route 16 general procedure 61, 2-amino-N-(5-fluoro-quinolin-8-yl)-4-trifluoromethyl-benzenesulfonamide (Intermediate 276) (200 mg, 0.52 mmol), t-butyl nitrite (0.09 ml, 0.78 mmol) and AcOH (2 ml) gave the title compound (20 mg, 11%) after purification by column chromatography with DCM/MeOH (98:2) as the eluent.

Provenance & Evidence