Acetic Acid → 9-Chloro-1-trifluoromethyl-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide

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Reaction Steps

In a similar fashion using route 16 general procedure 61, 2-amino-4-chloro-N-(4-trifluoromethyl-quinolin-8-yl)-benzenesulfonamide (Intermediate 280) (340 mg, 0.85 mmol), t-butyl nitrite (0.15 ml, 1.27 mmol), AcOH (4 ml), THF (4 ml) gave the title compound (60 mg, 18%) after purification by column chromatography with DCM/MeOH (98:2) as the eluent.

Provenance & Evidence