Acetic Acid → 9-Chloro-12-trifluoromethyl-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide

Participants

Reaction Steps

In a similar fashion using route 16 general procedure 61, 2-amino-4-chloro-N-(5-trifluoromethyl-quinolin-8-yl)-benzenesulfonamide (Intermediate 282) (340 mg, 0.85 mmol), t-butyl nitrile (0.15 ml, 1.27 mmol) and AcOH:THF (3.4 ml: 3.4 ml) gave the title compound (28 mg, 9%) after purification by column chromatography with DCM/MeOH (99.5:0.5) as the eluent.

Provenance & Evidence