Acetic Acid → 3-Chloro-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide

Participants

Reaction Steps

In a similar fashion using route 16 general procedure 61, 2-amino-N-(2-chloro-quinolin-8-yl)-benzenesulfonamide (Intermediate 283) (590 mg, 1.77 mmol), t-butyl nitrite (0.32 ml, 2.65 mmol) and AcOH:THF (5.9 ml: 5.9 ml) gave the title compound (80 mg, 16%) after purification by column chromatography with DCM/MeOH (99:1) as the eluent.

Provenance & Evidence