Acetic Acid → 3,9-Dichloro-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide

Participants

Reaction Steps

In a similar fashion using route 16 general procedure 61, 2-amino-4-chloro-N-(2-chloro-quinolin-8-yl)-benzenesulfonamide (Intermediate 287) (0.1 g, 0.27 mmol), t-butyl nitrite (0.05 ml, 0.41 mmol) and AcOH:THF (1 ml: 2 ml), gave the title compound (0.04 g, 45%) after purification by column chromatography with DCM/MeOH (90:10) as the eluent.

Provenance & Evidence