HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 60164546, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Tert-Butyl nitrite | HCID 10906 | — |
| Reactant | HCID 68183293 | HCID 68183293 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 60164546 | HCID 60164546 | 23.5% |
Reaction Steps
In a similar fashion using route 16 general procedure 61, 8-(2-amino-benzenesulfonylamino)-quinoline-4-carboxylic acid methyl ester (Intermediate 288) (270 mg, 0.75 mmol), t-butyl nitrite (0.14 ml, 1.13 mmol), AcOH (2.7 ml) and THF (2.7 ml) gave the title compound (60 mg, 23%) after purification by column chromatography with DCM/MeOH (99:1) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-53a9a76c7a3246fa86daadce8ddbe9bb |
| Source note | uspto-grants-2015_08 |