HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 5H-6-Thia-1,4,5-triaza-chrysene 6,6-dioxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Tert-Butyl nitrite | HCID 10906 | — |
| Reactant | 2-Amino-N-quinoxalin-5-yl-benzenesulfonamide | HCID 68183357 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5H-6-Thia-1,4,5-triaza-chrysene 6,6-dioxide | HCID 68183331 | 16.4% |
Reaction Steps
In a similar fashion using route 16 general procedure 61, 2-amino-N-quinoxalin-5-yl-benzenesulfonamide (Intermediate 304) (440 mg, 1.4 mmol), t-butyl nitrite (0.27 ml, 2.19 mmol), AcOH (4.5 ml) and THF (4.5 ml) gave the title compound (65 mg, 16%) after purification by column chromatography with DCM/MeOH (99:1) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-b04756c341914a48baf19d9980aa6e5e |
| Source note | uspto-grants-2015_08 |