Acetic Acid → 12-Chloro-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide

Participants

Reaction Steps

In a similar fashion using route 16 general procedure 61, 2-amino-N-(5-chloro-quinolin-8-yl)-benzenesulfonamide (Intermediate 295) (370 mg, 1.10 mmol), t-butyl nitrite (171 mg, 1.66 mmol), AcOH (3.7 ml) and THF (3.7 ml) gave the title compound (60 mg, 17%) after purification by column chromatography with n-hexane/DCM (1:1) as the eluent.

Provenance & Evidence