Acetic Acid → 8-Methyl-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide

Participants

Reaction Steps

In a similar fashion using route 16 general procedure 61, 2-amino-5-methyl-N-quinolin-8-yl-benzenesulfonamide (Intermediate 296) (160 mg, 0.51 mmol), t-butyl nitrite (80 mg, 0.76 mmol), AcOH (1.6 ml) and THF (1.6 ml) gave the title compound (20 mg, 13%) after purification by column chromatography with n-hexane/DCM (1:1) as the eluent.

Provenance & Evidence