Acetic Acid → 9-Fluoro-8-methyl-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide

Participants

Reaction Steps

In a similar fashion using route 16 general procedure 61, 2-amino-4-fluoro-5-methyl-N-quinolin-8-yl-benzenesulfonamide (Intermediate 299) (340 mg, 1.03 mmol), t-butyl nitrite (0.18 ml, 1.54 mmol), AcOH (3.4 ml) and THF (3.4 ml) gave the title compound (50 mg, 15%) after purification by column chromatography with DCM/MeOH (90:10) as the eluent.

Provenance & Evidence