Acetic Acid → HCID 24858488, compound

Participants

Reaction Steps

In a similar fashion using route 16 general procedure 61, 2-amino-N-quinolin-8-yl-5-trifluoromethyl-benzenesulfonamide (Intermediate 300) (330 mg, 0.9 mmol), t-butyl nitrite (0.16 ml, 1.3 mmol), AcOH (3.3 ml) and THF (3.3 ml) gave the title compound (25 mg, 7%) after purification by column chromatography with DCM/MeOH (99.8:0.2) as the eluent.

Provenance & Evidence