Tert-Butyl nitrite → 12-Chloro-9-trifluoromethyl-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide

Participants

Reaction Steps

In a similar fashion using route 16 general procedure 61, 2-amino-N-(5-chloro-quinolin-8-yl)-4-trifluoromethyl-benzenesulfonamide (Intermediate 302) (350 mg, 0.87 mmol), t-butyl nitrite (0.16 ml, 1.30 mmol) and AcOH (3.5 ml) gave the title compound (110 mg, 33%) after purification by column chromatography with DCM/MeOH/NH3 (99:1:2 drops) as the eluent.

Provenance & Evidence