Phosphorus pentachloride → HCID 68183263, compound

Participants

Reaction Steps

In the similar fashion using route 19 general procedure 42, 5-chloroquinolin-8-amine (Intermediate 27) (155 mg, 1.15 mmol), sodium (2,3-dimethylphenyl)sulfamate (Intermediate 21) (300 mg, 1.23 mmol), PCl5 (771 mg, 3.70 mmol), TEA (1.67 ml, 12.3 mmol) and toluene (10 ml) gave the title compound (24 mg, 7%) after purification by column chromatography with n-hexane/EtOAc (1:0-17:3) as the eluent followed by trituration from n-pentane.

Provenance & Evidence