6-Methoxy-8-quinolinamine → HCID 68183303, compound

Participants

Reaction Steps

In the similar fashion using route 19 general procedure 42, 6-methoxyquinolin-8-amine (Intermediate 23) (200 mg, 1.15 mmol), TEA (170 mg, 1.72 mmol), chlorosulfonic acid (150 mg, 1.27 mmol), PCl5 (260 mg, 1.72 mmol), DIPEA (300 mg, 2.23 mmol), 2,6-difluoroaniline (600 mg, 4.6 mmol) gave the title compound (15 mg, 4%) after purification by column chromatography with DCM/MeOH (1:0-97:3) as the eluent.

Provenance & Evidence