反应详情

NalO4 (11.71 g, 54.76 mmol) was added portionwise to a solution of dimethyl-[(E)-2-(8-nitro-quinolin-7-yl)-vinyl]-amine (Intermediate 203) (4.44 g, 18.3 mmol) in THF/water (1:1, 70 ml). The mixture was stirred at room temperature for 16 h. The insoluble material was removed by filtration and washed with EtOAc (60 ml). The combined organic phases were washed with sat. sodium bicarbonate solution, brine, dried (Na2SO4) and concentrated in vacuo to give the title compound (3.24 g, 71%).

1. customThe insoluble material was removed by filtration
2. washwashed with EtOAc (60 ml)
3. washThe combined organic phases were washed with sat. sodium bicarbonate solution, brine
4. dry with materialdried (Na2SO4)
5. concentrationconcentrated in vacuo