Trifluoromethanesulfonate → HCID 60164096, compound

HRID 513652Notes

Reaction equation

HRID 513652 reaction equation
[NH2:1][CH2:2][C:3]1[C:12]([NH2:13])=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1.N1([S:19](N2C=C[N+](C)=C2)(=[O:21])=[O:20])C=CN=C1.FC(F)(F)S([O-])(=O)=O>CC#N>[CH2:2]1[C:3]2[CH:4]=[CH:5][C:6]3[C:11](=[N:10][CH:9]=[CH:8][CH:7]=3)[C:12]=2[NH:13][S:19](=[O:21])(=[O:20])[NH:1]1

Participants

5

Reactant 3

HCID 2758875TrifluoromethanesulfonateHCID 11728150HCID 11728150, compoundHCID 68183296HCID 68183296, compound2×

Product 1

HCID 60164096HCID 60164096, compoundYield 6%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

7-Aminomethyl-quinolin-8-amine (Intermediate 211) (50 mg, 0.29 mmol) and 1-(1H-imidazole-1-sulfonyl)-3-methyl-1H-imidazol-3-ium; trifluoromethanesulfonate (157 mg, 0.43 mmol) in MeCN (5 ml) was stirred at room temperature for 18 h. The reaction mixture was concentrated in vacuo. The crude residue was purified by preparative HPLC (basic conditions) to give the title compound (4.5 mg, 6%).

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customThe crude residue was purified by preparative HPLC (basic conditions)

Sources & evidence

ORD record
ord-a81072e81dc74f008a55d7fc33eee212
Source dataset
uspto-grants-2015_08
Patent number
US09102688B2

Reaction notes

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