HuagongsheHuagongshe Chemistry Print Report · For research reference only
(8-Nitro-quinolin-7-yl)-phenyl-methanol → (8-Amino-quinolin-7-yl)-phenyl-methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (8-Nitro-quinolin-7-yl)-phenyl-methanol | HCID 68183066 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (8-Amino-quinolin-7-yl)-phenyl-methanol | HCID 68183272 | 99.4% |
Reaction Steps
Palladium on Carbon (10%, 38 mg) was added to a solution of (8-nitro-quinolin-7-yl)-phenyl-methanol (Intermediate 214) (500 mg, 1.78 mmol) in EtOH (20 ml) and the mixture was stirred under an atmosphere of hydrogen for 1.5 h. The mixture was diluted with MeOH (40 ml), filtered through celite and the filtrate was concentrated in vacuo to give the title compound (443 mg, 99%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-33e20e36a28542969dea9cd28396d563 |
| Source note | uspto-grants-2015_08 |