反应详情

N-Methylsulfamoyl chloride (414 mg, 3.2 mmol) was added to a suspension of (8-amino-quinolin-7-yl)-phenyl-methanol (Intermediate 215) (200 mg, 0.8 mmol) in pyridine (5 ml) and the reaction was stirred at room temperature for 16 h. The solution was concentrated in vacuo. The crude residue was purified by column chromatography, with heptane/EtOAc (90:10-50:50) gradient elution to give the title compound (20 mg, 8%).

1. concentrationThe solution was concentrated in vacuo
2. customThe crude residue was purified by column chromatography, with heptane/EtOAc (90:10-50:50) gradient elution