HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 68182987, compound → HCID 68183174, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 68182987 | HCID 68182987 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 68183174 | HCID 68183174 | 49.5% |
Reaction Steps
In a similar fashion using route 22 general procedure 55, 7-[(5-fluoropyridin-2-yl)carbonyl]-8-nitroquinoline (Intermediate 358) (1.43 g, 4.9 mmol) and 10% Pd—C (200 mg) in THF (60 ml) gave the title compound (648 mg, 43%) which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-a2fdcbcb90804371bfe74fae5f3d93a0 |
| Source note | uspto-grants-2015_08 |