反应详情

In a similar fashion using route 27 general procedure (Intermediate 70), (8-amino-quinolin-7-yl)-(4-trifluoromethyl-phenyl)-methanone (Intermediate 370) (40 mg, 0.13 mmol), N-methylsulamoyl chloride (Intermediate 213) (49 mg, 0.38 mmol) and NaBH4 (4.8 mg, 0.13 mmol) in pyridine (5 ml) gave the title compound (34 mg, 68%) after purification by preparative HPLC (acidic conditions 1).