HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → HCID 60164656, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | N-Methylsulfamoyl chloride | HCID 11789235 | — |
| Reactant | HCID 68183425 | HCID 68183425 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 60164656 | HCID 60164656 | 52% |
Reaction Steps
In a similar fashion using route 27 general procedure 70, (8-amino-quinolin-7-yl)-(6-trifluoromethyl-pyridin-3-yl)-methanone (Intermediate 371) (100 mg, 0.32 mmol), N-methylsulfamoyl chloride (Intermediate 213) (49 mg, 0.38 mmol) and NaBH4 (12 mg, 0.315 mmol) in pyridine (5 ml) gave the title compound (65 mg, 52%) after purification by preparative HPLC (acidic conditions 1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-ed24384bd89b4425b3df12501a7203e5 |
| Source note | uspto-grants-2015_08 |