HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → HCID 68183422, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | N-Methylsulfamoyl chloride | HCID 11789235 | — |
| Reactant | HCID 68183372 | HCID 68183372 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 68183422 | HCID 68183422 | 31.7% |
Reaction Steps
In a similar fashion using route 27 general procedure 70, (8-amino-quinolin-7-yl)-(3-fluoro-pyridin-4-yl)-methanone (Intermediate 372) (60 mg, 0.22 mmol), N-methylsulfamoyl chloride (Intermediate 213) (87 mg, 0.67 mmol) and NaBH4 (8.5 mg, 0.22 mmol) in pyridine (5 ml) gave the title compound (24 mg, 31%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-ef54807ef31643fd8757fab135dc75ba |
| Source note | uspto-grants-2015_08 |