HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → HCID 68183308, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | N-Methylsulfamoyl chloride | HCID 11789235 | — |
| Reactant | HCID 68183174 | HCID 68183174 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 68183308 | HCID 68183308 | 6.9% |
Reaction Steps
In a similar fashion using route 27 general procedure 70, 7-[(5-fluoropyridin-2-yl)carbonyl]-8-aminoquinoline (Intermediate 373) (648 mg, 2.4 mmol), N-methylsulfamoyl chloride (Intermediate 213) (942 mg, 7.2 mmol) and NaBH4 (92 mg, 2.4 mmol) in pyridine (10 ml) gave the title compound (57 mg, 2.2%) after purification by preparative HPLC (acidic conditions).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-23293bef6b29481a9add58f8e0217407 |
| Source note | uspto-grants-2015_08 |