Sodium borohydride → HCID 68183038, compound

Participants

Reaction Steps

In a similar fashion using route 27 general procedure 70, (8-amino-quinolin-7-yl)-(3-chloro-4-fluoro-phenyl)-methanone (Intermediate 376) (80 mg, 0.27 mmol), N-methylsulfamoyl chloride (Intermediate 213) (103 mg, 0.8 mmol) and NaBH4 (10 mg, 0.27 mmol) in pyridine (3 ml) gave the title compound (35 mg, 35%) after purification by preparative HPLC (acidic conditions 1).

Provenance & Evidence