HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → HCID 60163576, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | N-Methylsulfamoyl chloride | HCID 11789235 | — |
| Reactant | HCID 68183200 | HCID 68183200 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 60163576 | HCID 60163576 | 49% |
Reaction Steps
In a similar fashion using route 27 general procedure 70, 7-[(3, 4difluorophenyl)carbonyl]-8-aminoquinoline (Intermediate 377) (100 mg, 0.35 mmol), N-methylsulfamoyl chloride (Intermediate 213) (105 mg, 1.0 mmol) and NaBH4 (14 mg, 0.34 mmol) in pyridine (4 ml) gave the title compound (62 mg, 47%) after purification by preparative HPLC (acidic conditions 1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-00ead225f1f04e188f73b5708012d37b |
| Source note | uspto-grants-2015_08 |