Sodium borohydride → HCID 68183289, compound

Participants

Reaction Steps

In a similar fashion using route 27 general procedure 70, 7[(4-trifluoromethoxyphenyl)carbonyl]-8-aminoquinoline (Intermediate 378) (100 mg, 0.31 mmol), N-methylsulfamoyl chloride (Intermediate 213) (105 mg, 1.0 mmol) and NaBH4 (14 mg, 0.34 mmol) in pyridine (4 ml) gave the title compound (70 mg, 56%) after purification by preparative HPLC (acidic conditions 1).

Provenance & Evidence