HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → HCID 68183278, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | N-Methylsulfamoyl chloride | HCID 11789235 | — |
| Reactant | HCID 68183353 | HCID 68183353 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 68183278 | HCID 68183278 | 16% |
Reaction Steps
In a similar fashion using route 27 general procedure 71, (8-amino-quinolin-7-yl)-(4-fluoro-2-methyl-phenyl)-methanone (Intermediate 380) (200 mg, 0.71 mmol), N-methylsulfamyl chloride (Intermediate 213) (700 mg, 5.4 mmol), NaBH4 (81 mg, 2.14 mmol) and pyridine (6 ml) gave the title compound (40 mg, 16%) after purification by preparative HPLC (neutral conditions).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-934d43554ac84e6a8b9a6a40df95a647 |
| Source note | uspto-grants-2015_08 |