Sodium borohydride → HCID 68183142, compound

Participants

Reaction Steps

In a similar fashion using route 27 general procedure 71, (8-amino-quinolin-7-yl)-(3-fluoro-4-methoxy-phenyl)-methanone (Intermediate 381) (200 mg, 0.6 mmol), N-methylsulfamyl chloride (Intermediate 213) (260 mg, 2.0 mmol), NaBH4 (76 mg, 2.0 mmol) and pyridine (2 ml) gave the title compound (130 mg, 52%) after purification by column chromatography with n-hexane/EtOAc (50:50) as the eluent.

Provenance & Evidence