Hydrochloric Acid → (8-Amino-5-chloro-quinolin-7-yl)-(4-fluoro-phenyl)-methanone

Participants

Reaction Conditions

Reaction Steps

N-Chlorosuccinimide (0.12 g, 0.93 mmol) was added to a solution of (8-amino-quinolin-7-yl)-(4-fluoro-phenyl)-methanone 367 (0.25 g, 0.93 mmol) in CCl4 (3 ml) followed by HCl (cat) and the mixture was heated at 80° C. for 4 h. After cooling, the mixture was quenched with water and the aqueous phase was extracted with EtOAc. The organic phase was washed with brine, dried (Na2SO4) and concentrated in vacuo. The crude residue was purified by column chromatography with DCM as the eluent to give the title compound (0.1 g, 43%).

Provenance & Evidence