HCID 68183329, compound → HCID 68183270, compound

HRID 513690Notes

Reaction equation

HRID 513690 reaction equation
[N+:1]([C:4]1[C:5]([CH:14]([OH:16])[CH3:15])=[CH:6][CH:7]=[C:8]2[C:13]=1[N:12]=[CH:11][CH:10]=[CH:9]2)([O-])=O>O=[Mn]=O.C(Cl)Cl>[NH2:1][C:4]1[C:5]([C:14](=[O:16])[CH3:15])=[CH:6][CH:7]=[C:8]2[C:13]=1[N:12]=[CH:11][CH:10]=[CH:9]2

Participants

4

Reactant 1

HCID 68183329HCID 68183329, compound

Product 1

HCID 68183270HCID 68183270, compoundYield 78%

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 6344DichloromethaneSolvent

Procedure

In a similar fashion using route 27 general procedure 68, 1-(8-nitro-quinolin-7-yl)-ethanol 409 (200 mg, 1.06 mmol), MnO2 (925 mg, 10.63 mmol) and DCM (5 ml) gave the title compound (150 mg, 78%) which was used in the next step without further purification.

Sources & evidence

ORD record
ord-7671c96e488d424eae6e93ba85ae07d6
Source dataset
uspto-grants-2015_08
Patent number
US09102688B2

Reaction notes

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