Sodium borohydride → 1-Ethyl-2-methyl-1,4-dihydro-2H-3-thia-2,4,5-triaza-phenanthrene 3,3-dioxide

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Reaction Steps

In a similar fashion using route 27 general procedure 71, 1-(8-amino-quinolin-7-yl)-propan-1-one 410 (300 mg, 1.6 mmol), N-methylsulfamyl chloride 213 (1 g, 7.7 mmol) and NaBH4 (20 mg, 0.54 mmol) gave the title compound (40 mg, 10%) after purification by column chromatography with DCM/MeOH (99:1) as the eluent.

Provenance & Evidence