HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → HCID 68183348, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | N-Methylsulfamoyl chloride | HCID 11789235 | — |
| Reactant | HCID 68183270 | HCID 68183270 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 68183348 | HCID 68183348 | 14.2% |
Reaction Steps
In a similar fashion using route 27 general procedure 71, 1-(8-amino-quinolin-7-yl)-ethanone 411 (200 mg, 1.07 mmol), N-methylsulfamyl chloride 213 (700 mg, 5.40 mmol), NaBH4 (79 mg, 2.13 mmol) and pyridine (10 ml) gave the title compound (40 mg, 13%) after purification by column chromatography with DCM/MeOH (99:1) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-c156ee37a74641b7a2c9fd71a337bd1c |
| Source note | uspto-grants-2015_08 |