N,N-Dimethylethylenediamine → HCID 178483763, compound

Participants

Reaction Steps

N,N dimethylethylenediamine (2.5 ml, 3.37 mmol) and Ti(OEt)4 (1.16 ml, 5.46 mmol) were added to a solution of (4-fluoro-phenyl)-(8-nitro-quinolin-7-yl)-methanone 352 (400 mg, 1.35 mmol) in DCM/THF(10 ml:40 ml) under an argon atmosphere and the mixture was stirred at room temperature for 18 h. The mixture was poured into EtOAc/brine and the resulting solution was filtered through celite. The solid residue was washed with EtOAc. The combined organic phases were washed with brine, dried (Na2SO4) and concentrated in vacuo to give the title compound (414 mg, 91%) which was used in the next step without further purification.

Provenance & Evidence