Sodium borohydride → HCID 68183317, compound

Participants

Reaction Conditions

Reaction Steps

NaBH4 (181 mg, 4.9 mmol) was added to a solution of N-[1-(8-amino-quinolin-7-yl)-1-(4-fluoro-phenyl)-meth-(E)-ylidene]-N′,N′-dimethyl-ethane-1,2-diamine 414 (550 mg, 1.63 mmol) in EtOH (12 ml) at 0° C. and the mixture was heated at 80° C. for 4 h. After cooling, the reaction was quenched with water and the aqueous phase was extracted with EtOAc. The organic phase was washed with brine, dried (Na2SO4) and concentrated in vacuo. The crude residue was purified by column chromatography with DCM/MeOH (97:3) to give the title compound (420 mg, 75%).

Provenance & Evidence