Sulfamide → HCID 68183430, compound

Participants

Reaction Conditions

Reaction Steps

Sulfamide (272 mg, 2.84 mmol) was added to a solution of N-[(8-amino-quinolin-7-yl)-(4-fluoro-phenyl)-methyl]-N′,N′-dimethyl-ethane-1,2-diamine 415 (160 mg, 0.47 mmol) in pyridine (1.5 ml) and the mixture was heated at 120° C. for 1.5 h in a sealed tube. After cooling, the solvent was removed in vacuo. The crude residue was purified by column chromatography with DCM/MeOH (98:2) to give the title compound (35 mg, 18%).

Provenance & Evidence