Hydrochloric Acid → HCID 88861907, compound

Participants

Reaction Conditions

Reaction Steps

6 M HCl (5 ml) was added dropwise to a solution of 1-(3-[1,3]dioxolan-2-yl-4-fluoro-phenyl)-2-methyl-1,4-dihydro-2H-3-thia-2,4,5-triaza-phenanthrene 3,3-dioxide 421 (390 mg, 0.94 mmol) in THF (10 ml) and the mixture was heated at 70° C. for 3 h. After cooling, the mixture was neutralised with sat K2CO3 and the aqueous phase was extracted with EtOAc (30 ml). The organic phase was washed with brine (10 ml), dried (Na2SO4) and concentrated in vacuo. The crude residue was purified by column chromatography with DCM/MeOH (95:5) as the eluent to give the title compound (180 mg, 52%).

Provenance & Evidence