Acetic Acid → HCID 68183006, compound

Participants

Reaction Steps

AcOH (23.1 μl, 0.4 mmol) was added dropwise to a solution of 2-fluoro-5-(2-methyl-3,3-dioxo-1,2,3,4-tetrahydro-3λ*6*-thia-2,4,5-triaza-phenanthren-1-yl)-benzaldehyde 422 (50 mg, 0.13 mmol), MnO2 (176 mg, 2.02 mmol), and sodium cyanide (66 mg, 1.35 mmol) in MeOH (10 ml). The mixture was stirred at room temperature for 3 h. The mixture was filtered and the filtrate was diluted with water (10 ml). The mixture was extracted with EtOAc (15 ml, ×2) and DCM (15 ml). The combined organic phases were concentrated in vacuo to give the title compound (50 mg, 93%) which was used in the next step without further purification.

Provenance & Evidence