HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → HCID 68183315, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | HCID 88861907 | HCID 88861907 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | HCID 68183315 | HCID 68183315 | 10.5% |
Reaction Steps
In a similar fashion using route 37 general procedure 90, 2-fluoro-5-(2-methyl-3,3-dioxo-1,2,3,4-tetrahydro-3λ*6*-thia-2,4,5-triaza-phenanthren-1-yl)-benzaldehyde 422 (50 mg, 0.13 mmol), piperazine (12 mg, 0.13 mmol) and sodium triacetoxyborohydride (40 mg, 0.19 mmol) in DCE (2 ml) gave the title compound (6 mg, 10%) after purification by preparative HPLC (acidic conditions 1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-a890813e05bf4454aadb6810f6f35dc3 |
| Source note | uspto-grants-2015_08 |